Description

Cardio Essentials Niacin SR supports cardiovascular health by promoting healthy lipid metabolism.◆ Niacin, also known as nicotinic acid, has been used for many decades to support heart health, endothelial function, and immune function.◆ Extensive clinical studies show that sustained release versions of niacin promote reduced facial flushing.◆

The ingredients in Cardio Essentials Niacin SR are dosed in a manner that is congruous with what research suggests to be effective and safe, particularly for supporting cardiovascular health.◆

Clinical evidence and research cited herein shows that the ingredients in Cardio Essentials Niacin SR may:

• Support cardiovascular health◆
• Support healthy lipid/energy metabolism◆
• Support healthy immune function◆
• Promote reduced facial flushing◆
• Promote antioxidant activity◆

How Cardio Essentials Niacin SR Works
Cardio Essentials Niacin SR promotes healthy lipid metabolism.3,4
Research shows that niacin also promotes healthy endothelial function.5
Endothelial cells play a role in cardiovascular
health by supporting nitric oxide production and availability.5,6 Endothelial cells help support healthy vascular and
immune functions critical for cardiovascular health through membrane-bound receptors such as proteins, particles
transported by lipids, metabolites, and hormones.7
Cardio Essentials Niacin SR also supports healthy immune responses and is a potent antioxidant by promoting nuclear
transcription factors.3
Research shows that niacin’s antioxidant activity promotes healthy white blood cells, which
in turn supports healthy energy metabolism and healthy immune function.8

Why Use Cardio Essentials
Niacin SR?
The ingredients in Cardio Essentials Niacin SR are dosed
in a manner that is congruous with what research suggests
to be effective and safe, particularly for supporting
cardiovascular health.

Other Ingredients: Vegetable waxes (rice bran and/
or carnauba), vegetable stearic acid, vegetable
magnesium stearate, silica.
Directions: Take one tablet with a meal one to two
times daily or as directed by your healthcare
practitioner.
Caution: Temporary flushing, itching, or warming
of the skin may occur. If you are pregnant, nursing,
or taking medication, consult your healthcare
practitioner before use. Keep out of reach of children.
Serving Size: 1 Tablet
Servings Per Container: 60
Ingredients: Amount %DV*
Niacin (as nicotinic acid) 500 mg NE 3,125%

References:
1. Miller, M. (2003). Niacin as a component of combination therapy for dyslipidemia. Mayo
Clinic Proceedings, 78(6), 735-742.
2. Kim, S.-H., Kim, M.-K., Lee, H.-Y., Kang, H.-J., Kim, Y.-J., Park, B.-J., & Kim, H.-S. (2011).
Efficacy and tolerability of a new extended-release formulation of nicotinic acid in Korean
adults with mixed dyslipidemia: An 8-week, multicenter, prospective, randomized,
double-blind, and placebo-controlled trial. Clinical Therapeutics, 33(10), 1357-1364.
3. Meyers, C. D., Kamanna, V. S., Kashyap, M. L. (2004). Niacin therapy in atherosclerosis.
Current Opinion in Lipidology, 15(6), 659-665.
4. Superko, H. R., Zhao, Z.-Q., Hodis, H. N., & Guyton, J. R. (2017). Niacin and heart disease
prevention: Engraving its tombstone is a mistake. Journal of Clinical Lipidology, 11(6),
1309-1317.
5. Gomarasch, M., Ossoli, A., Adorni, M. P., Damonte, E., Niesor, E., Veglia, F., Franceschini,
G., Benghozi, R., Calabresi, L. (2015). Fenofibrate and extended-release niacin improve
the endothelial protective effects of HDL in patients with metabolic syndrome. Vascular
Pharmacology, 74, 80-86.
6. Hadi, A. R., Carr, C. S., & Suwaidi, J. A. (2005). Endothelial dysfunction: Cardiovascular
risk factors, therapy, and outcome. Vascular Health and Risk Management, 1(3), 183-198.
7. Peramaiyan, R., Thamaraiselvan, R., Jayakumar, T., Yutaka, N., Dhanapal, S., Gautam, S.,
& Ikuo, N. (2013). The vascular endothelium and human diseases. International Journal of
Biological Sciences, 9(10), 1057-1069.
8. Shobha H.Ganji, S. H., Vaijinath S.Kamanna, V. S., & Kashyap, M. L. (2014). Niacin
decreases leukocyte myeloperoxidase: Mechanistic role of redox agents and Src/p38MAP
kinase. Atherosclerosis, 235(2), 554-561.