Peptides help the body function properly, working a lot like hormones. Some, like Sermorelin and Ipamorelin, support natural growth hormone production for anti-aging and healing. Others, like BPC-157 and TB-500, are great for brain, gut, and joint health. GLP-1 peptides can help with fat loss, but they need to be used correctly to avoid issues like muscle loss or mood changes.

There are also peptides with more specific benefits, like HCG, which can help restore fertility, and Melanotan II, which boosts tanning and may protect the skin. The key takeaway is that peptides can be really effective, but they need to be used with the right knowledge and approach to get the best results.

Highlights of the Podcast

00:05 – Peptides Overview

01:48 – Growth & Healing Peptides

04:46 – GLP-1 Peptides & Fat Loss

09:08 – HCG & Fertility

10:38 – Melanotan II for Skin

12:25 – Optimizing Peptide Use

Dr. Matt Chalmers [00:00:05] Let’s talk about peptides. So there’s a bunch of different peptides basically there. You need to think of them more like hormones than anything else. They tell the body what to do. There are codes that kind of come in and drag the body where you want to go. So some of my favorite peptides. The small and I formalin the sucker cogs that help your body produce more natural growth hormone. Probably one of my favorites. The the upsides and downsides on those is they’re fantastic for anti-aging. They’re really, really good for healing. The small and I formalin mix is my personal favorite. Test them all in fine you know the small and I put them in by themselves are fine. CJC is fine. I just personally the mix of the small and I can see the short acting the long acting function. Those have been my favorite. It’s what I use the last year. What we use for anti-aging. A lot of the dosages on anti-aging and like bodybuilding stuff are obviously different. Most people, you know, we do point one, let’s see, it’s a five by five mix. So there’s ten milligrams in there by 3 to 3.3. 0.3mg is usually what we’ll do for anti-aging. Men and women, body weight does kind of determine what’s going on there. And then obviously, I like to stack that on top of testosterone. Testosterone is the the primary healing hormone that your body has. So getting that level where it’s supposed to be first is important. And then adding the anti-aging small line hormone on top is really, really great.

Dr. Matt Chalmers [00:01:48] One of the ones I like now, the copper peptide, the g K copper peptides, the you is fantastic. Lots of people are using it for hair replacement hair regrowth and it’s great. The research on it’s really, really good. I like it because it increases oxygen. Anything that increases oxygen, I’m going to be a fan of. That’s where I’m it’s such a big fan of Methylene Blue. That’s why I’m such a big fan of Coke ten and hyperbaric Oxygen and CPAp and all that jazz. So if you can increase oxygen, I’m going to be a fan. So the copper peptides are fantastic. And like I said, the research is actually pretty good on them. Helping restore hair growth. I see. What are some of the other ones that we’ve been using lately? The BP 157 is is really weird. Like my nurse practitioner, that’s all she uses for her arthritis. She got off all of our other drugs, all medical, normal medical drugs and Celebrex and Humana and all that stuff, and also uses the 157, which is great. I’ve also got people who have used it and didn’t like I. I don’t feel that much. So if I use it more for brain health and for gut function, so like ulcerative colitis, for dementia, for Alzheimer’s, for, you know, traumatic brain injury and stuff like that, I mix the BP 157 with the TB 500 and that’s what we use forgotten brain a lot. And that’s been really, really helpful. So that’s probably my favorite mix for. Nerve functions of gut and brain function.

Dr. Matt Chalmers [00:03:18] But lots and lots of people are taking it for joint inflammation, joint pain like that. If you’re a guy and you’re on TRT Deca nearly a decade later, Deca still my favorite for joint function. Women can’t really take it. It drops their voice too much. But it’s a it’s one of my favorites for joints for guys. So we carry that one. If you guys are looking for that, nobody else has it. We’ve we’ve got it. We my my team prescribes it so the neck is pretty great. The now we get into like the GOP ones there’s like everybody’s coming out and talking about how all these GOP ones are terrible. They’re fantastic. It’s glucagon. The problem we get into is that people don’t know anything about metabolic biochemistry. The easiest way to tell someone knows what they’re talking about is that they start telling you about calories. You need to not listen to them. You cannot you cannot use GOP ones on a calorie based idea because if you if you’re starting to go down the calorie road, you’re going to most likely miss the idea that all of the fat that’s on you, all of the muscle that’s on you, the interplay, that metabolic function is derived by two hormones, insulin and glucagon. The G from GLP is glucagon, GOP says for glucagon like peptide. So if you don’t know what glucagon is, it basically it’s what tells your body to make its own sugar and to burn fat instead of sugars for fuel.

Dr. Matt Chalmers [00:04:46] So once you understand that function, you understand what the body does to burn fat and what it does to create sugar, then the liver issues, the muscle wasting also makes complete sense. But if you’re based on the idea that the body uses calories as a fuel source, you’re going to hurt people. Because we don’t understand ATP is the practice is the actual chemical or body uses for energy, then you’re obviously not going to understand how it’s created. And if you don’t understand how ATP is created, you’re not going to understand life, politics and glycolytic ATP production. And so that’s the basis of metabolism. So you’re just going to be hurting people. So a lot of the issues that we see with GLP one being dangerous and hurting people is because the people who are using them. Whether that’s the dock or the provider or whatever, they didn’t understand how they actually worked, and so they weren’t able to properly educate the patient on what they should do and shouldn’t do. So that’s a big one. Real quick, on those who are going to use them. I highly recommend you get you to sjöström where it’s supposed to be first, then learn the diet you’re supposed to be on if you’re if you’re and then no more often you’re overweight because of that stuff. You’re most likely going to need to be moved to a lower glycemic diet. And then then you can, you know, take care of the extra bile. You need extra B6 for liver function. You have to make sure that you’re getting enough protein or collagen in throughout the day so it doesn’t eat your muscle tissues.

Dr. Matt Chalmers [00:06:12] So and if you don’t if your provider hasn’t gone over that stuff, you need to find somebody else to walk you through how to use JP’s or you’re going to end up with results you’re not super happy with. The other thing is you need to be checking in at least once a month with these guys to make sure that somebody is following up on your mental state. GOP ones have a fantastic ability to reduce cravings and addictions and things like that, but they do it by blunting the dopamine reward system, which is also what gives you joy throughout the day and makes you happy that you’ve done the things you’ve done. So. You know, it’s easy to track. It’s it’s kind of rare that it actually creates that big of a deficit. But if people aren’t watching that and taking out for it, you’re you’re going to have issues. So so those peptides are great as well. AP Alan, so sorry on the GOP ones. Semaglutide Drugs, appetite, risk, appetite are all great are GOP ones. There’s new returning tide that’s coming out. There’s a dip. It’s a little different. I’m a little bit up in the air on that one. I’m not super excited about all the research that’s come out because I don’t think there’s been enough research. The idea of the GOP ones is that they’re going to increase glucagon function and insulin function. So theoretically they could be really useful for like type ones, but.

Dr. Matt Chalmers [00:07:32] The vast majority of the problem we have in this country is overproduction of insulin. And that’s what’s driving the diabetes issues. That’s what’s driving the obesity issues. That’s what’s driving the dementia and the Alzheimer’s. The mood issues is what’s driving a lot of the PCOS issues. It’s what’s driving there’s new research out there saying that’s linked to autism and things like that. So which makes complete sense. So the. Increasing somebody’s ability to produce insulin is not. Not first on my list of things we should be doing. But we’ll see how that one plays out. I’m not for or against that one yet. I don’t have enough research on it, but the gap is, well, we’ll go over that later if they become important. The upper echelon is really, really cool. The epithelial on peptide helps to lengthen telomeres, which is been really, really closely linked to anti-aging. So the longer telomere, the the easier it is for you about your DNA to replicate. And so the chances of you living longer are higher, according to the research on telomere function. So I think that one’s pretty cool. The ACG is being classified as a peptide now from from a lot of places. I’m saying which. Fine. I mean, it’s a hormone, but peptides are so close to hormones. I mean, it’s six one way after the other. ACG is fantastic. The medical community reclassified that as a biologic so that no one could make it, even though it is the number one best way to increase fertility in men and women. Apparently the government does not want us having more babies.

Dr. Matt Chalmers [00:09:08] So, I mean, lots of evidence of that. But ACG is fantastic. It’s what we use. Like I’ll use it for people who’ve been on testosterone for years and they have no fertility left, and then we’ll wane them off the testosterone or whatever androgens they’re on. And we bring up the CG, increasing the function of the testicles again. And then they’re they become fertile again. That’s how we do it with bodybuilders, how we do with pretty much everybody. So that’s what I did whenever I wanted to have kids. So, you know, it’s a great, great, great peptide or hormone. So if you don’t have ACG, that’s a great one to get. Let’s see, what are the other ones we’ve been using lately? So I am a personal fan because I’m super white. I’m Scottish, which is weird because I also have a lot of Native American Cherokee in me. I’m melatonin too, has been really, really cool. It helps increase melanin in your skin so you tan easier and faster, which is a great. I like to use it as well. As a as a preventative for like skin damage and burns and skin cancer and stuff like that. So the melatonin two is really cool. That one’s fun. If you guys haven’t if you guys aren’t familiar with that one, learn about that. And the only thing on that one is that it’s going to increase melanin where you have melanin. And so the problem we run into is that if you’ve got these little like, white specks on you, those white specks usually don’t get much better with melatonin to ensure it ends up happening as you get darker because you can still see the white specks.

Dr. Matt Chalmers [00:10:38] For some reason, tanning naturally kind of helps blend those through. But as far as getting Tanner, it’s a pretty solid play. I really like it. So what else are we doing? That’s more or less so on the GOP ones. I love GOP ones as I like fixing diabetes and like fixing dementia. That’s one of my favorite things to do. I still like Semaglutide. I know cause Appetite has a lot of benefit to it. It’s all fine and has less, you know, got issues and stuff. One of the big issues that I see with it is the way that people are using it. One giant bolus, a weak injection of semaglutide is not my favorite way to do it. You can actually dial in the amount and the function a lot easier with daily injections. And it’s it’s it’s an insulin needle, so it’s not that big of a deal. You can use you can actually use more per week with less side effects doing them daily than doing one giant injection all at once. So it’s the same idea of like with testosterone. I always recommend that people don’t do one shot a week that they do, you know, 2 or 3 two’s easier shots because of the half life of testosterone. And, you know, if you’re like, we want to be at 2000, are you going to take a whole bunch of test all at once to get there and stay there? So you’re going to have a lot more side effects because you gave it a whole lot more all at once in the body has to deal with it all at once. So it’s going to, you know, shove it off into estrogen and DHT and other things. But if you use a lower dose more often, you’re going to get more function and a little bit less conversion and side effects with those hormones.

Dr. Matt Chalmers [00:12:25] So it’s similar in that regard, but that’s kind of how we play it out. I mean, we’ve been in a really, really good success with it and we haven’t had a whole lot of side effects. But then again, we’re also doing everything else to make sure that the body functions where it’s supposed to. Again, I can’t beat this horse enough. If if you’re if you’re a practitioner, your provider is talking about calories when you’re using GOP ones. The chances are you’re going to get hurt are significantly higher because if they think that the body runs on calories, they have no idea that metabolic function and this is a really powerful metabolic tool. So you don’t want people using tools. They have no idea how the tools work. So just halfway on that one, do you guys have any questions drop in the comments or [email protected], Tomorrow is friday as questions Anyway, so we will see you guys then. Have a great day. Thanks for your time.

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Dr. Matt Chalmers

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