Dr Chalmers Path to Pro – More Peptide Questions

Peptides can be powerful tools for supporting metabolism, weight management, and muscle preservation, but using them safely requires proper guidance. Key points include starting with small doses, preparing injections correctly, and paying attention to how your body responds to avoid common side effects.

Certain peptides, like GLP-1 compounds, can help reduce hunger, support fat loss, and even improve issues like PCOS and endometriosis when combined with proper nutrition, exercise, and growth hormone support. With the right approach, it’s possible to maximize benefits while minimizing risks.

This Article first ran on the Pillars of Wellness Substack

Check out the video there.

Highlights of the Podcast

00:01 – Introduction to Peptides

01:14 – Injection Site Issues

02:31 – Dosing Safety

03:45 – GLP-1 Peptides (e.g., Semaglutide)

04:58 – Nutritional Support for Weight Loss

06:05 – Side Effects and Exercise

07:21 – Growth Hormone & Muscle Preservation

08:32 – Alternatives for Female Athletes

09:44 – Nutrition & Cofactors

11:10 – Working with Experienced Professionals

12:22 – Peptides & Women’s Health

Dr. Matt Chalmers [00:00:04] All right, so the vast majority of the questions I’ve been getting about peptides. Peptides are growing, everybody’s talking about them. So the number one thing I can tell you to do with these is to work with someone who knows what they’re doing with them. I realize how silly that sounds, how like, well, obviously that’s what you should do, but that’s honestly what you shouldn’t do. I’ll get calls from people who, you know, oh, my friend did this online, they got this stuff online and it really messed them up. Well, okay. Peptides are powerful. If you don’t know what you’re doing with them, you know, they’re not like a supplement where you take it and like, Oh, I got a little bit. Yep. No, it’s these things are more powerful than that. So make sure you’re working with someone who knows what they’re doing with them. Start off. Some of the big issues we’ve been getting, people are having issues with the injection site. That is oftentimes not because of the peptide, but because of them make the water you use to mix it with. Benzal alcohol has… Benzene, things like that, have a big reaction point for a lot of people. So changing the injection fluid that you’re using to reconstitute these things is a big part of why people have issues.

Dr. Matt Chalmers [00:01:14] So again, when you’re working with somebody and you have these reactions, they can go, oh, I know what that is. This is what you have to do to fix it. So that’s a big issue. And then the way things are dosed, I’m not trying to argue with people that, oh, I got success. Fine. All right. Like, I see a lot of people talking about dosing stuff online, ways I would never dose it. You know, you got to take a lot or it’s not going to work. That is horrible advice for vast majority of the peptides. You’re going to take it all at once, as much as you can. Don’t do that. Small amounts give small reactions. Big amounts give big reactions. If you don’t know what the reaction is going to be or you don t know how sensitive you are to that particular peptide, taking a bunch of it is really stupid. Some of this I just feel like is really common sense, but apparently that’s not what’s on the internet. Yeah, but here’s the thing, once you know how your body responds, you can increase the dose. If you’ve never done them, how do you know you’re not going to have a reaction to the water or to the peptide or anything else that you’re taking with it or how you’re using it or when during the day you’re supposed to take it.

Dr. Matt Chalmers [00:02:31] Or what to do whenever you have reactions guys get with somebody who knows what they’re going with these nets and that might be your medical doctor it might not be it’s probably not but do work with people who understand what’s going on with these things so there’s a lot of these things like I said that are fantastic you know Semiclutide’s great, trazepatide is great, retrutide is my favorite, but it’s also great. How you use these things is really important. So for instance, let’s roll back to the one that we’ve all heard about that’s FDA approved so I can talk about without getting too much trouble. Let’s talk about semiglutide. Okay, semigglutide was the primary one that everybody’s been using for a long time. It’s worked really, really well. It’s a GLP-1. It has upsides and downsides. The number one thing that I saw as a problem with it was people were being overdosed was the primarily thing. The secondary thing is that they were given no support. Okay. Let’s walk through this real quickly. When you take a GLP-1, some of the things that are going to happen that you kind of want to happen is it’s going to start blocking that ghrelin hormone that tells your body you’re hungry. And so it usually increases leptin. That’s more information most people care about.

Dr. Matt Chalmers [00:03:45] But anyway, what ends up happening is that you’re just not hungry. Fantastic! So you’re going to eat less. Great! Here’s the problem. If you go into this in the glucose fed state and your muscles and your bones and everything your body’s still running on sugar Your body is going to create a higher level of sugar, which means it’s going to tear apart your muscle tissues at a much higher level If you’re not on a growth hormone adjunct, if you’re on testosterone, if you are not consuming the proper amount of nutrition during the day, which is minerals and D3 and CoQ10 and protein and all the things your body requires to run, it’s gonna tear apart your muscle tissues at a much higher level. And so this whole 40 to 50% of the weight loss that we saw with semi-glutide was from lean muscle mass, that’s why. Because whoever was working with you on this, if anybody, didn’t explain to you, Hey, when you force the body to start doing this thing, then it hasn’t done it a long time. You need to supply the chemistry that your body is going to use to do these things, which is minerals, B vitamins, specifically B6 for a lot of this fat stuff, B2 is important, folic acid is critically important as well for the whole process. But that’s one of the big things. This cholecystic sinus people were getting was one, from an overdose issue, two, they got no liver support.

Dr. Matt Chalmers [00:04:58] So here’s the thing. Most people who were taking this were taking it because they weren’t processing It’s that fast though. Well, so guess what, if you if you go out and walk around the block once a day for 10 minutes and you’re like, Oh, I do some exercise and then you go do a hardcore two hour workout that you know, when your bodybuilder buddies wrote you, you’re not gonna be able to walk for two days, because you did way more than your body’s used to. So if you’re already not used to processing and burning fat and doing all these things, and then force it into the system. And then you wonder why it fails, or you wonder why you’re writing 8 on your muscle tissue, because… You didn’t supply the body with the chemistry that it required to do the job you’re asking it to do. And here’s the thing, yeah, your body will tear apart your muscle tissues to get the protein to make sugar for your blood. Happens all the time, it’s easy, it is not that big of a deal, but here’s another thing. Your body will also rip apart your muscles tissues to the minerals that are inside so they can process and fuel the liver to do the processes that you’re asking it to do. And sometimes, if you don’t feed the body the nutrients it requires, it creates a ton of waste. Well your body has to de-nature and move that waste out as well.

Dr. Matt Chalmers [00:06:05] So it’ll, again, rip apart your muscle tissues to get the minerals and stuff like that. When you’re doing these things, a lot of the side effects are because people were not either dosed properly or they didn’t get the support they needed, they didn’t exercise and things like that. So on the growth hormone adjuncts, taking them at the wrong time is problematic. And here’s the crazy thing about that. Some people need to take it before they work out. Some people needed to take in the morning. Most people need it take it at night. You can do them both. You can a little bit of the morning at night and it benefits in different ways. But it depends on what type of workout you’re doing, when you’re going it and what your goals are. So like growth hormone is fantastic to offset the issues we see with the GLP-1s. So, and you can pick your peptide, CJC 1295, Epimoryl and. Some more than Tesla more than it doesn’t really matter for this process, it matters what’s best for your body. But at the end of the day, if you’re gonna take these just for to prevent muscle loss, nighttime is awesome. Just take them at night, you’ll end up with a little bit better sleep function, and you’re going to end up with maintaining a lot of your muscle mass because your body naturally produces this stuff at night because your bodies set up to process, regenerate, repair and heal at night while you’re asleep.

Dr. Matt Chalmers [00:07:21] So, taking it, you know. 15, 20 minutes, 30 minutes before you go to bed, so that it starts producing while you’re asleep, way to go, good job. Now, but here’s the thing, if your liver’s not really healthy and it has all the stuff it needs, it’s hard for your body to take that growth hormone your brain produces and turn it into IGF-1 in your liver, which is what your body’s actually using, that’s insulin-like growth factor one, to repair and heal everything. So, again, when you take these things is really important. How much you take is also important. So the first time I always have people take a little bit and be like, okay, like two hours for bed, tell me how you feel, tell me if you have flushing, if your gut does twirly stuff, if you, you know, have loose stools or whatever, like here’s the fixes for all those things. But that’s kind of how we walk through that one. If you’re, one of the things we use all the time, especially in our female athletes. And female bodybuilders and stuff, is we get a lot of these women who come in and are like, hey, I want to run Anivar. And I’m like, I love Anivars. Anivare’s a fantastic tool. If you use it right, it’s awesome. It’s, if you support the liver, it’s not bad in the liver the whole deal. The problem with Anivara, especially for women, problem with the eyes too, but mostly with women, is it’s highly androgenic, which means you’re gonna lose your hair.

Dr. Matt Chalmers [00:08:32] Well, so one of the things we’ve started switching to is instead of using Anivore, why don’t we run your test like you’re normally doing it and then add in some of the growth hormone adjuncts, like I just mentioned. And bring up your body’s ability to burn fat and build muscle tissue that way because you can also do those in a You know in a lower fed sticks, you know, so you’re you’re your calorie deficit, which I use that term So people know what it is, but it is the dumbest calories of the dumb thing in the world. Anyway That helps out maintain muscle function because it’s telling you right to regenerate the stuff. It’s tearing apart but again You guys need to really, if you’re gonna do a cut like that, you’re going to start eating a lot less. If you’re eating these GLP ones, semi-glutatide, tricepidide, reddish, even red. And reddish rootide is fantastic. It’s much better at preserving the muscle mass than the rest of them. But you still have to make sure that you’re getting in the body’s requirement function. So, you know, we always check testosterone levels or we give options for CJ. I usually use CJC and epimoralin, so you can use your growth hormones for that. You’re doing some type of exercise and you’re consuming protein. And it doesn’t really, you don’t have to eat like three steaks a day.

Dr. Matt Chalmers [00:09:44] It’s not that type of deal. It is like, are you getting in some of the protein throughout the day to maintain this? Because again, muscle tissue, the things you got to work on, worry about are minerals, proteins probably last, but protein is one. You know, and then all the cofactors, CoQ10, you know, glutathione, so you take your NAC and stuff like that. So these are some of things we got to walk on. So biggest thing, if you guys want to maximize your utilization, and maximize your safety, and get the results you’re trying to get. Work with people who know what they’re doing on this. People who’ve worked with a lot of other people, work with people that have gone, work with the bodybuilders. If your person who you’re working with has not worked with any bodybuilder, I don’t know if they’ve worked with very many people, because the peptides have been around for a long time in the bodybuilding community. And you’re going to get the vast majority of your actual knowledge, research, and information on tolerances and stuff like that, and what’s been done and what has worked with your bodybuilding community. So those are the guys I’d make sure that you’re working with the most. The only downside of that is that that’s the only people they’ve worked with. That might be a little bit catalyzed as well because most of your bodybuilders are used to eating a pretty strict diet, exercising, and they understand how their body feels when they introduce new chemicals and stuff to them. But that’s where a lot of this is.

Dr. Matt Chalmers [00:11:10] A lot of the dangers and all the issues people are seeing is because either person didn’t understand what was going to happen when they put the peptide in and not like, oh, you’re going to lose weight. Okay, what’s the chemical process? What is actually going to go on? What do we need to support? What do need to make sure that you’re aware of? How do we deal with symptoms, issues when they come up? Because a lot of these things are driven by your symptomatology. It’s when you feel this, do that. When you feel, this take this instead. When you do this, for instance, nausea. The intensity of the knowledge on some of these weight loss things is a good key indicator. You want it to be very low. You wouldn’t be like, if I just sit and think about it, I have it, but not like it, it preoccupies my mind. I’m trying to do stuff in the day and I feel nauseous. Like that’s too much. Um, you’re in the wrong spot. You know, if you shut down the gut function completely, that’s obviously bad. That’s the wrong slot. It’s too. Um, and you got to figure out how you personally are going to figure out that your gut is shut off. Um. These are a lot of the things, like I said, you can buy these things online and you can use them and you have great success, but you can also have a lot problems because again, these things aren’t dangerous, they’re powerful.

Dr. Matt Chalmers [00:12:22] So just make sure that you’re working with people who know what they’re doing and you can end up getting great results. These peptides are the key to metabolic function. We can literally turn things on, turn things off, increase things, decrease things. We’ve been able to see phenomenal side, you know. A side effect is something that we weren’t necessarily going for, but we got. And so one of the things that’s actually a side effect that we’ve seen with PCOS and endometriosis with some of these GLP ones, uh, is the PCOS and endometreosis calms way down because as soon as you get those, those glucose and the sugar levels and the insulin resistance kind of put back where they’re supposed to be, all of a sudden, what we start seeing is these women are like, oh my gosh, you had one call me and she was like, she was, like, I started my cycle today. And I’m like, great. She’s like, no, no. Don’t hurt. She’s like I can feel it. She was like, but I’m not curled up in the bathroom floor anymore And this is the thing that was very very common for her Because she has PCOS But it’s a fantastic these are fantastic tools Just make sure that you get with people who know if they’re going with them and you guys are gonna have really good success So if you guys have any other questions to this up, I got some on stem cells But we’re doing that stem cell thing on Monday. So well, we should answer all those questions then you guys a fantastic time And be safe

As always if you have any questions, please send them to Questions@ChalmersWellness.com

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Dr. Matt Chalmers

Disclaimer: This content is for informational purposes only. Before taking any action based on this information you should first consult with your physician or health care provider. This information is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health providers with any questions regarding a medical condition, your health, or wellness